谷胱甘肽过氧化酶4重组兔单抗

bsm-61552R

重组兔单抗

GPX4 Recombinant Rabbit mAb

谷胱甘肽过氧化酶4重组兔单抗

GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx; mtPHGPx; GPX4_HUMAN; GPX4; Glutathione peroxidase 4 (GPx-4 | GSHPx-4); 1.11.1.12; GPX4_MOUSE; GPX4_RAT;

Rabbit

A synthesized peptide derived from human GPX4: 18-65/197

IgG

Liquid

affinity purified by Protein A

Recombinant

12H13

22

17

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

谷胱甘肽过氧化物酶（GSH-Px）是机体内广泛存在的一种重要的过氧化物分解酶。硒是GSH-Px酶系的组成成分，它能催化GSH变为GSSG，使有毒的过氧化物还原成无毒的羟基化合物，同时促进H2O2的分解，从而保护细胞膜的结构及功能不受过氧化物的干扰及损害。GSH-Px的活性中心是硒半胱氨酸，其活力大小可以反映机体硒水平。GSH-Px酶系主要包括4种不同的GSH-Px，分别为胞浆GSH-Px、血浆GSH-Px、磷脂氢过氧化物GSH-Px及胃肠道专属性GSH-Px。胞浆GSH-Px由4个相同的分子量大小为22kDa的亚基构成四聚体，每个亚基含有1个分子硒半胱氨酸，广泛存在于机体内各个组织，以肝脏红细胞为最多。它的生理功能主要是催化GSH参与过氧化反应，清除在细胞呼吸代谢过程中产生的过氧化物和羟自由基，从而减轻细胞膜多不饱和脂肪酸的过氧化作用。

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.