载脂蛋白C3重组兔单抗
Rrmab®兔单抗
货号：bsm-61543R
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概述
产品编号
bsm-61543R
产品类型
重组兔单抗
英文名称
APOC3 Recombinant Rabbit mAb
中文名称
载脂蛋白C3重组兔单抗
英文别名
APOCIII; Apo-C3; ApoC-3; apo-CIII; apoC-III; APOC3_HUMAN; APOC3; Apolipoprotein C3; APOC3_MOUSE; APOC3_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Apolipoprotein C3: 55-99/99
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8F1
理论分子量
11
检测分子量
11
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins
Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins > Apolipoproteins
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
APOC3
蛋白名
Apolipoprotein C-III
亚细胞定位
Secreted.
组织特异性
Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
翻译后修饰
O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
疾病
Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the apolipoprotein C3 family.
功能
Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
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