Important transcription factor regulating the expression of genes involved in immune and inflammatory responses.
基因名
CEBPB
蛋白名
CCAAT/enhancer-binding protein beta
亚基
Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B.
亚细胞定位
Nucleus.
组织特异性
Expressed at low levels in the lung, kidney and spleen.
翻译后修饰
Sumoylated by polymeric chains of SUMO2 or SUMO3.
相似性
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.
功能
Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation.