ATG4C Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-61516R
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概述
产品编号
bsm-61516R
产品类型
重组兔单抗
英文名称
ATG4C Recombinant Rabbit mAb
中文名称
自噬相关蛋白4C重组兔单抗
英文别名
APG4-C; APG4C; AUTL1; AUTL3; HsAPG4C; Atg4cl; ATG4C_HUMAN; ATG4C; AUT-like 3 cysteine endopeptidase; Autophagy-related cysteine endopeptidase 3 (Autophagin-3); Autophagy-related protein 4 homolog C (HsAPG4C); 3.4.22.-; ATG4C_MOUSE; Autophagy-related protein 4 homolog C;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ATG4C: 350-458/458
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
18B10
理论分子量
52 kDa
检测分子量
52 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Autophagy > APG gene products
Cancer > Cell Death > Autophagy > Signal Transduction
Cancer > Oncoproteins/suppressors > Oncoproteins > Cell survival & death
Cancer > Signal transduction > Autophagy
Cardiovascular > Heart > Autophagy > APG gene products
Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
ATG4C
蛋白名
Cysteine protease ATG4C
亚细胞定位
Cytoplasm (Probable).
组织特异性
Highly expressed in skeletal muscle, heart, liver and testis.
相似性
Belongs to the peptidase C54 family.
功能
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
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