促凋亡BNIP3L蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-61515R
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概述
产品编号
bsm-61515R
产品类型
重组兔单抗
英文名称
BNIP3L Recombinant Rabbit mAb
中文名称
促凋亡BNIP3L蛋白重组兔单抗
英文别名
BNIP3a; NIP3L; NIX; D14Ertd719e; UV93; BNI3L_HUMAN; BNIP3L; Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X (NIP3L); BNIP3H; BNI3L_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human BNIP3L: 150-219
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
19B20
理论分子量
24
检测分子量
35
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family
Cancer > Oncoproteins/suppressors > Tumor suppressors > p53 pathway
Cardiovascular > Heart > Apoptosis
Cell Biology > Apoptosis > Intracellular > Bcl2 Family
Cell Biology > Apoptosis > Intracellular > p53 Pathway
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitophagy fission and fusion
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
BNIP3L
蛋白名
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
亚基
Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).
亚细胞定位
Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein (Potential). Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
翻译后修饰
Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
相似性
Belongs to the NIP3 family.
功能
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
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