成纤维细胞核受体Nr5a2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
成纤维细胞核受体Nr5a2重组兔单抗
货号:bsm-61508R
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概述

产品编号
bsm-61508R
产品类型
重组兔单抗
英文名称
NR5A2 Recombinant Rabbit mAb
中文名称
成纤维细胞核受体Nr5a2重组兔单抗
英文别名
B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; LRH1; hB1F-2; D1Ertd308e; UF2-H3B; mFTF; NR5A2_HUMAN; NR5A2; Alpha-1-fetoprotein transcription factor; B1-binding factor (hB1F); CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1 (LRH-1); NR5A2_MOUSE; Fetoprotein transcription factor (mFTF); NR5A2_RAT; FTZ-F1 beta;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human NR5A2: 450-524
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7B10
理论分子量
61
检测分子量
65
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
成纤维细胞核受体Nr5a2重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
NR5A2
蛋白名
Nuclear receptor subfamily 5 group A member 2
亚细胞定位
Nucleus.
组织特异性
Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and hepG2 cells.
相似性
Belongs to the nuclear hormone receptor family. NR5 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
功能
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

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