CLTC Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

bsm-61487R

重组兔单抗

CLTC Recombinant Rabbit mAb

网格蛋白重链重组兔单抗

CHC; CHC17; CLH-17; CLTCL2; Hc; MRD56; 3110065L21Rik; CLH1_HUMAN; CLTC; Clathrin heavy chain on chromosome 17 (CLH-17); CLH17; KIAA0034; CLH1_MOUSE; CLH1_RAT; clathrin heavy chain; clathrin, heavy polypeptide (Hc); clathrin, heavy chain; clathrin, heavy polypeptide-like 2; clathrin, heavy chain (Hc)

Rabbit

A synthesized peptide derived from human Clathrin heavy chain 1: 204-256

IgG

Liquid

affinity purified by Protein A

Recombinant

19G19

192,187 kDa

190 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Clathrin heavy chain proteins are composed of several functional domains, including a carboxy-terminal region that permits interaction with other heavy chain proteins within a triskelion, and a globular amino-terminal region that associates with other vesicle proteins. Adaptor proteins, such as AP2, epsin and EPS15, are responsible for the recruitment of vesicle proteins to sites of pit formation and the assembly of the clathrin-coated vesicle.

CLTC

Clathrin heavy chain 1

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL. Interacts with ERBB2 (By similarity).

Cytoplasmic vesicle membrane. Membrane > coated pit. Melanosome. Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the clathrin heavy chain family.
Contains 7 CHCR (clathrin heavy-chain) repeats.

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.