葡萄糖-6磷酸脱氢酶重组兔单抗
Rrmab®兔单抗
货号：bsm-61479R
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概述
产品编号
bsm-61479R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Glucose 6 Phosphate Dehydrogenase Recombinant Rabbit mAb
中文名称
葡萄糖-6磷酸脱氢酶重组兔单抗
英文别名
CNSHA1; G6PD1; G28A; G6pd; Gpdx; G6pdx; G6PD_HUMAN; 1.1.1.49; G6PD1_MOUSE; G6pd-1; G6PD_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human G6PD: 460-515/515
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9E20
理论分子量
59
检测分子量
59
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates
Cardiovascular > Atherosclerosis > Diabetes associated
Cardiovascular > Heart > Cardiac metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Types of disease > Diabetes
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
G-6-PD（Glucose-6-phosphate Dehydrogenase）。一种存在於人体红血球内，协助葡萄糖进行新陈代谢之酵素，在这代谢过程中会产生一种叫NADPH的物质能以保护红血球免受氧化物质的威胁。 G6PD缺乏时，若身体接触到具氧化性的特定物质或服用了这类药物，红血球就容易被破坏而发生急性溶血反应。
背景资料
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:200-500 | |
| IHC-F | Human | 1:200-500 | |
| IF | Human | 1:200-500 | |
| Flow-Cyt | Human | 1:50-100 |
交叉反应
交叉反应: Human
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靶标
基因名
G6PD
蛋白名
Glucose-6-phosphate 1-dehydrogenase
亚基
Homodimer or homotetramer.
组织特异性
Isoform Long is found in lymphoblasts, granulocytes and sperm.
疾病
Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.
相似性
Belongs to the glucose-6-phosphate dehydrogenase family.
功能
Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.
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