ATG3 Recombinant Rabbit mAb (一抗) - WB,ICC/IF | Bioss

bsm-61474R

重组兔单抗

ATG3 Recombinant Rabbit mAb

自噬相关蛋白3重组兔单抗

APG3; APG3-LIKE; APG3L; PC3-96; hApg3; 2610016C12Rik; Atg3l; PIG-1; Pig1; ATG3_HUMAN; ATG3; Autophagy-related protein 3 (APG3-like | hApg3); Protein PC3-96; 2.3.2.-; ATG3_MOUSE; Autophagy-related protein 3 (APG3-like); ATG3_RAT; Preconditioning-inducible gene 1 protein; autophagy related 3; APG3 autophagy 3-like (S. cerevisiae); ATG3 autophagy related 3 homolog (S. cerevisiae)

Rabbit

A synthesized peptide derived from human ATG3: 1-30

IgG

Liquid

affinity purified by Protein A

Recombinant

9B3

36 kDa

37 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ATG3

Ubiquitin-like-conjugating enzyme ATG3

Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Interacts with FNBP1L.

Cytoplasm.

Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.

Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.

Belongs to the ATG3 family.

E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.