自噬相关蛋白3重组兔单抗
Rrmab®兔单抗
货号：bsm-61474R
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概述
产品编号
bsm-61474R
产品类型
重组兔单抗
英文名称
ATG3 Recombinant Rabbit mAb
中文名称
自噬相关蛋白3重组兔单抗
英文别名
APG3; APG3-LIKE; APG3L; PC3-96; hApg3; 2610016C12Rik; Atg3l; PIG-1; Pig1; ATG3_HUMAN; ATG3; Autophagy-related protein 3 (APG3-like | hApg3); Protein PC3-96; 2.3.2.-; ATG3_MOUSE; Autophagy-related protein 3 (APG3-like); ATG3_RAT; Preconditioning-inducible gene 1 protein;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ATG3: 1-30
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9B3
理论分子量
36
检测分子量
40
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Autophagy > APG gene products
Cancer > Cell Death > Autophagy > Signal Transduction
Cancer > Oncoproteins/suppressors > Tumor suppressors
Cancer > Signal transduction > Autophagy
Cardiovascular > Heart > Autophagy > APG gene products
Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products
Neuroscience > Neurology process > Neurodegenerative disease
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ATG3
蛋白名
Ubiquitin-like-conjugating enzyme ATG3
亚基
Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Interacts with FNBP1L.
亚细胞定位
Cytoplasm.
组织特异性
Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
翻译后修饰
Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy.
相似性
Belongs to the ATG3 family.
功能
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
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