X射线修复交叉互补蛋白重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
X射线修复交叉互补蛋白重组兔单抗
货号:bsm-61465R
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概述

产品编号
bsm-61465R
产品类型
重组兔单抗
英文名称
XRCC1 Recombinant Rabbit mAb
中文名称
X射线修复交叉互补蛋白重组兔单抗
英文别名
RCC; SCAR26; Xrcc-1; XRCC1_HUMAN; XRCC1; X-ray repair cross-complementing protein 1; XRCC1_MOUSE; XRCC1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human XRCC1: 1-50/633
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5C16
理论分子量
69
检测分子量
90
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
XRCC-1是一种重要的DNA修复基因,在一系列内外氧化剂(包括烟草成分)导致的DNA单链断裂和碱基损伤修复中起到重要作用,是目前肿瘤研究的重要的蛋白。
背景资料
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity.
X射线修复交叉互补蛋白重组兔单抗X射线修复交叉互补蛋白重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
ICC/IFHumanMouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
XRCC1
蛋白名
DNA repair protein XRCC1
亚基
Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
亚细胞定位
Nucleus. Note=Accumulates at sites of DNA damage.
翻译后修饰
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.
相似性
Contains 2 BRCT domains.
功能
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

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