钙调磷酸酶A/钙依赖磷酸酶A重组兔单抗
Rrmab®兔单抗
货号：bsm-61464R
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概述
产品编号
bsm-61464R
产品类型
重组兔单抗
英文名称
PPP3CA Recombinant Rabbit mAb
中文名称
钙调磷酸酶A/钙依赖磷酸酶A重组兔单抗
英文别名
ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1; DEE91; IECEE; IECEE1; PPP2B; 2900074D19Rik; CN; CnA; PP2BA_HUMAN; PPP3CA; CAM-PRP catalytic subunit; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform (CNA alpha); Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; 3.1.3.16; PP2BA_MOUSE; PP2BA_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PPP3CA: 470-521/521
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12D3
理论分子量
59
检测分子量
59
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent, calcium-activated, serine/threonine protein phosphatase composed of a catalytic subunit (calcineurin A) and a tightly bound regulatory subunit (calcineurin B). Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PPP3CA
蛋白名
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
亚基
Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.
亚细胞定位
Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.
组织特异性
Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.
相似性
Belongs to the PPP phosphatase family. PP-2B subfamily.
功能
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
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