PPP3CA Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61464R

重组兔单抗

PPP3CA Recombinant Rabbit mAb

钙调磷酸酶A/钙依赖磷酸酶A重组兔单抗

ACCIID; CALN; CALNA; CALNA1; CCN1; CNA1; DEE91; IECEE; IECEE1; PPP2B; 2900074D19Rik; CN; CnA; PP2BA_HUMAN; PPP3CA; CAM-PRP catalytic subunit; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform (CNA alpha); Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; 3.1.3.16; PP2BA_MOUSE; PP2BA_RAT; protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase 2B, catalytic subunit, alpha isoform

Rabbit

A synthesized peptide derived from human PPP3CA: 470-521/521

IgG

Liquid

affinity purified by Protein A

Recombinant

12D3

59 kDa

60 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent, calcium-activated, serine/threonine protein phosphatase composed of a catalytic subunit (calcineurin A) and a tightly bound regulatory subunit (calcineurin B). Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.

PPP3CA

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.

Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.

Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle.

Belongs to the PPP phosphatase family. PP-2B subfamily.

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.