GATA结合蛋白4重组兔单抗
Rrmab®兔单抗
货号：bsm-61462R
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概述
产品编号
bsm-61462R
产品类型
重组兔单抗
英文名称
GATA4 Recombinant Rabbit mAb
中文名称
GATA结合蛋白4重组兔单抗
英文别名
ASD2; TACHD; TOF; VSD1; Gata-4; GATA4_HUMAN; GATA4; GATA-binding factor 4; GATA4_MOUSE; GATA4_RAT; DNA-binding protein GATA-GT2;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GATA4: 5-48
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
18D13
理论分子量
45
检测分子量
54
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Oncoproteins/suppressors > Tumor suppressors
Cardiovascular > Cardiovascular Markers
Cardiovascular > Cardiovascular Markers > Cell Markers > Cardiomyocytes
Cardiovascular > Heart > Hypertrophy > Transcription factors
Developmental Biology > Lineage specification > Endoderm
Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
GATA-4属于转录调节性因子，表达在心组织、胃肠道组织中，并调节该类T细胞的发育和功能。
背景资料
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function.In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
GATA4
蛋白名
Transcription factor GATA-4
亚基
Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.
亚细胞定位
Nucleus.
翻译后修饰
Methylation at Lys-300 attenuates transcriptional activity.
疾病
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.
相似性
Contains 2 GATA-type zinc fingers.
功能
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.
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