GATA4 Recombinant Rabbit mAb (一抗) - WB,ICC/IF | Bioss

bsm-61462R

重组兔单抗

GATA4 Recombinant Rabbit mAb

GATA结合蛋白4重组兔单抗

ASD2; TACHD; TOF; VSD1; Gata-4; GATA4_HUMAN; GATA4; GATA-binding factor 4; GATA4_MOUSE; GATA4_RAT; DNA-binding protein GATA-GT2; GATA binding protein 4; GATA-binding protein 4

Rabbit

A synthesized peptide derived from human GATA4: 5-48

IgG

Liquid

affinity purified by Protein A

Recombinant

18D13

45 kDa

60 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GATA-4属于转录调节性因子，表达在心组织、胃肠道组织中，并调节该类T细胞的发育和功能。

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function.In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression.

GATA4

Transcription factor GATA-4

Interacts with ZNF260. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes.

Nucleus.

Methylation at Lys-300 attenuates transcriptional activity.

Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Contains 2 GATA-type zinc fingers.

Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.