PABP2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,IP | Bioss
Rrmab?兔单抗
货号：bsm-61457R
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概述
产品编号
bsm-61457R
产品类型
重组兔单抗
英文名称
PABP2 Recombinant Rabbit mAb
中文名称
多聚腺苷酸结合蛋白2重组兔单抗
英文别名
OPMD; PAB2; PABII; PABP-2; PABP2; Pabp; Pabp+; PABP2_HUMAN; PABPN1; Poly(A)-binding protein 2; Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II (PABII); Polyadenylate-binding nuclear protein 1; PABP2_MOUSE; poly(A) binding protein nuclear 1; poly(A)-binding protein, nuclear 1; poly(A) binding protein, nuclear 1
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PABP 2: 4-31
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5G10
理论分子量
33 kDa
检测分子量
48 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding
Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing
Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing
Epigenetics and Nuclear Signaling > RNAi > P bodies/GW bodies
Epigenetics and Nuclear Signaling > Transcription > Other factors
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity).Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity).Increases the affinity of poly(A) polymerase for RNA.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:1000-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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暂无相关产品
靶标
基因名
PABPN1
蛋白名
Polyadenylate-binding protein 2
亚基
May interact with SETX (PubMed:21700224). Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A). Interacts with PAPOLA, but only in presence of oligo(A) RNA. Interacts with transportin. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Association in a ternary complex with CPSF4 and influenza A virus NS1 blocks pre-mRNAs processing, thereby preventing nuclear export of host cell mRNAs. Associates in a single complex with SKIP and MYOD1 and interacts with SKIP in differentiated myocytes. Interacts with NUDT21/CPSF5.
亚细胞定位
Cytoplasmic and Nuclear.
组织特异性
Ubiquitous.
翻译后修饰
Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties (By similarity).
疾病
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:A form of late-onset slowly progressive myopathy characterized by eyelid ptosis, dysphagia and, sometimes by other cranial and limb-muscle involvement.
相似性
Contains 1 RRM (RNA recognition motif) domain.
功能
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).
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