维生素D3受体重组兔单抗
Rrmab®兔单抗
货号：bsm-61452R
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概述
产品编号
bsm-61452R
产品类型
重组兔单抗
英文名称
Vitamin D3 receptor Recombinant Rabbit mAb
中文名称
维生素D3受体重组兔单抗
英文别名
NR1I1; PPP1R163; VDR_HUMAN; VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR_MOUSE; VDR_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Vitamin D3 receptor: 45808/427
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
14E4
理论分子量
48
检测分子量
48
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors
Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Vitamin D Receptor
Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger
Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Vitamin D Receptor
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat)
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靶标
基因名
VDR
蛋白名
Vitamin D3 receptor
亚基
Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.
亚细胞定位
Nucleus.
疾病
Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
相似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Contains 1 nuclear receptor DNA-binding domain.
功能
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone ensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
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