Smoothelin Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

bs-13740R

宠物抗体、农牧业/家禽抗体

Smoothelin Rabbit pAb

平滑肌蛋白抗体

smsmo; SMTN_HUMAN; SMTN; SMTN_MOUSE; smoothelin

Rabbit

KLH conjugated synthetic peptide derived from human Smoothelin: 851-917/917

IgG

Liquid

affinity purified by Protein A

Polyclonal

100 kDa

115 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The cytoskeletal protein smoothelin is highly conserved among vertebrates and is expressed exclusively by contractile smooth muscle cells where it localizes to the filament network. Smoothelin associates with actin stress fibers but does not interact with desmin. At least two isoforms of smoothelin are produced by alternative splicing. The short isoform lacks amino acids 1–544 at the amino-terminus of the long isoform. The short isoform is expressed in visceral muscle tissue, including intestine and stomach, but not in brain, while the long isoform is expressed in all vascularized organs. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. The gene encoding human smoothelin maps to chromosome 22q12.2.