PDIA6 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-61392R
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概述
产品编号
bsm-61392R
产品类型
重组兔单抗
英文名称
PDIA6 Recombinant Rabbit mAb
中文名称
蛋白二硫异构酶A6重组兔单抗
英文别名
ERP5; P5; TXNDC7; 1700015E05Rik; CaBP5; CaBP1; PDIA6_HUMAN; PDIA6; Endoplasmic reticulum protein 5 (ER protein 5 | ERp5); Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; 5.3.4.1; PDIA6_MOUSE; PDIA6_RAT; Calcium-binding protein 1 (CaBP1);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PDIA6: 1-50
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12F4
理论分子量
48 kDa
检测分子量
48 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
May function as a chaperone that inhibits aggregation of misfolded proteins.Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling.May also regulate the UPR via the EIF2AK3 UPR sensor.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Rat | Mouse | 1:100-500 |
| IHC-F | Human, Rat | Mouse | 1:100-500 |
| IF | Human, Rat | Mouse | 1:100-500 |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PDIA6
蛋白名
Protein disulfide-isomerase A6
亚基
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation.
亚细胞定位
Endoplasmic reticulum.
组织特异性
Expressed in platelets (at protein level).
相似性
Belongs to the protein disulfide isomerase family.
Contains 2 thioredoxin domains.
Contains 2 thioredoxin domains.
功能
May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
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