PDIA6 | ERp5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF | Bioss

bsm-61392R

重组兔单抗

PDIA6 | ERp5 Recombinant Rabbit mAb

蛋白二硫异构酶A6重组兔单抗

ERP5; P5; TXNDC7; 1700015E05Rik; CaBP5; CaBP1; PDIA6_HUMAN; PDIA6; Endoplasmic reticulum protein 5 (ER protein 5 | ERp5); Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; 5.3.4.1; PDIA6_MOUSE; PDIA6_RAT; Calcium-binding protein 1 (CaBP1); protein disulfide isomerase family A member 6; thioredoxin domain containing 7 (protein disulfide isomerase); protein disulfide isomerase-associated 6; protein disulfide isomerase family A, member 6; protein disulfide isomerase-related protein

Rabbit

A synthesized peptide derived from human PDIA6: 1-50

IgG

Liquid

affinity purified by Protein A

Recombinant

12F4

48 kDa

48 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

May function as a chaperone that inhibits aggregation of misfolded proteins.Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling.May also regulate the UPR via the EIF2AK3 UPR sensor.

PDIA6

Protein disulfide-isomerase A6

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells. Interacts with ITGB3 following platelet stimulation.

Endoplasmic reticulum.

Expressed in platelets (at protein level).

Belongs to the protein disulfide isomerase family.
Contains 2 thioredoxin domains.

May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.