JUP | gamma Catenin Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-61391R

重组兔单抗、宠物抗体

JUP | gamma Catenin Recombinant Rabbit mAb

γ-连环素/连接蛋白γ重组兔单抗

CTNNG; DP3; DPIII; PDGB; PG; PKGB; D930025P04Rik; PLAK_HUMAN; JUP; Catenin gamma; Desmoplakin III; Desmoplakin-3; PLAK_MOUSE; PLAK_RAT; junction plakoglobin; catenin (cadherin-associated protein), gamma 80kDa; desmosomal protein 3

Rabbit

A synthesized peptide derived from human gamma Catenin: 1-130/745

IgG

Liquid

affinity purified by Protein A

Recombinant

2C6

82 kDa

82 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞骨架的微丝E-cad通过相关蛋白α、β、γ-cat经羟基端在细胞内与细胞骨架的微丝连接形成E-cad/cat）复合体，参与细胞粘附、生长、增殖等过程.

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue.

JUP

Junction plakoglobin

Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form.

Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.

May be phosphorylated by FER.

Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.

Belongs to the beta-catenin family.
Contains 9 ARM repeats.

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.