Integrin alpha 4 Recombinant Rabbit mAb (一抗) | Bioss
Rrmab?兔单抗
货号：bsm-61373R
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概述
产品编号
bsm-61373R
产品类型
重组兔单抗
英文名称
Integrin alpha 4 Recombinant Rabbit mAb
中文名称
整合素α4（CD49d）重组兔单抗
英文别名
CD49D; IA4; Itga4B; ITA4_HUMAN; ITGA4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; ITA4_MOUSE; Lymphocyte Peyer patch adhesion molecules subunit alpha (LPAM subunit alpha);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Integrin alpha 4: 1000-1032
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6F8
理论分子量
115 kDa
检测分子量
140-150 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
整合素-α-4型 Integrin α4 (CD49d)整合素-α是介导细胞与细胞外基质粘附作用的主要因子。
背景资料
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human
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靶标
基因名
ITGA4
蛋白名
Integrin alpha-4
亚基
Heterodimer of an alpha and a beta subunit.
亚细胞定位
Membrane; Single pass type I membrane protein.
翻译后修饰
Phosphorylation on Ser-1027 inhibits PXN binding.
相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 7 FG-GAP repeats.
功能
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
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