O6甲基鸟嘌呤DNA甲基转移酶重组兔单抗

bsm-61358R

重组兔单抗

MGMT Recombinant Rabbit mAb

O6甲基鸟嘌呤DNA甲基转移酶重组兔单抗

MGMT_HUMAN; MGMT; 6-O-methylguanine-DNA methyltransferase (MGMT); O-6-methylguanine-DNA-alkyltransferase; 2.1.1.63;

Rabbit

A synthesized peptide derived from human MGMT: 1-45/207

IgG

Liquid

affinity purified by Protein A

Recombinant

3F8

22

22

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

O-6-methylguanine-DNA methyltransferase(MGMT)O-6-甲基鸟嘌呤-DNA-甲基转移酶:是广泛存在于细菌到哺乳动物机体中的一种独特DNA修复酶，MGMT是一种DNA修复酶，是突变和癌变的抑制因子。它对烷化剂导致的DNA损伤有修复作用。 MGMT是突变和癌基因的抑制因子。研究表明MGMT水平与恶性肿瘤的发生、进展、浸润、预后及治疗有密切关系。细胞中MGMT水平与其所能耐受的DNA损伤密切相关。一般来讲，低水平表达MGMT的肿瘤可以应用烷化剂药物治疗；反之则为耐药。在正常组织中，肝脏高表达；脑组织和骨髓低水平表达。

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.