Integrin alpha 5 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss

bsm-61357R

重组兔单抗、mIHC精品抗体

Integrin alpha 5 Recombinant Rabbit mAb

整合素α5（CD49e）重组兔单抗

CD49e; FNRA; VLA-5; VLA5A; VLA5; Itga5_retired; ITA5_HUMAN; ITGA5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; ITA5_MOUSE; integrin subunit alpha 5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); fibronectin receptor, alpha polypeptide

Rabbit

A synthesized peptide derived from human Integrin alpha 5: 1000-1049

IgG

Liquid

affinity purified by Protein A

Recombinant

8G1

115 kDa

140 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ITG-α5粘附分子整合素α5也是细胞粘附分子的超家族成员，广泛分布于细胞表面和细胞外基质的糖蛋白,不仅介导细胞与细胞或细胞与基质之间的连接,而且参与细胞间的信号转导,细胞的生长移行,肿瘤的转移浸润,免疫炎性反应,血管生成等一系列的生理和病理过程。

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.

ITGA5

Integrin alpha-5

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat.

Membrane; Single-pass type I membrane protein.

Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.

CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling.