整合素α5（CD49e）重组兔单抗
Rrmab®兔单抗
货号：bsm-61357R
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概述
产品编号
bsm-61357R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Integrin alpha 5 Recombinant Rabbit mAb
中文名称
整合素α5（CD49e）重组兔单抗
英文别名
CD49e; FNRA; VLA-5; VLA5A; VLA5; Itga5_retired; ITA5_HUMAN; ITGA5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; ITA5_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Integrin alpha 5: 1000-1049
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8G1
理论分子量
115
检测分子量
150
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
ITG-α5粘附分子整合素α5也是细胞粘附分子的超家族成员，广泛分布于细胞表面和细胞外基质的糖蛋白,不仅介导细胞与细胞或细胞与基质之间的连接,而且参与细胞间的信号转导,细胞的生长移行,肿瘤的转移浸润,免疫炎性反应,血管生成等一系列的生理和病理过程。
背景资料
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ITGA5
蛋白名
Integrin alpha-5
亚基
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat.
亚细胞定位
Membrane; Single-pass type I membrane protein.
相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 7 FG-GAP repeats.
功能
CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling.
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