细胞分裂周期蛋白25B重组兔单抗
Rrmab®兔单抗
货号：bsm-61332R
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概述
产品编号
bsm-61332R
产品类型
重组兔单抗
英文名称
CDC25B Recombinant Rabbit mAb
中文名称
细胞分裂周期蛋白25B重组兔单抗
英文别名
MPIP2; MPIP2_HUMAN; CDC25B; Dual specificity phosphatase Cdc25B; 3.1.3.48; CDC25HU2; MPIP2_MOUSE; Cdc25m2; MPIP2_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human CDC25B: 175-250
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
理论分子量
65
检测分子量
64
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| Flow-Cyt | Human | Mouse | 1:50-100 |
| IP | Human, Mouse | 1:20-50 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
CDC25B
蛋白名
M-phase inducer phosphatase 2
亚基
Interacts with MAPK14 and 14-3-3 proteins.
亚细胞定位
Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole.
翻译后修饰
Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
相似性
Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.
Contains 1 rhodanese domain.
功能
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
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