Cdc25B Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,IP | Bioss

bsm-61332R

重组兔单抗

Cdc25B Recombinant Rabbit mAb

细胞分裂周期蛋白25B重组兔单抗

MPIP2; MPIP2_HUMAN; CDC25B; Dual specificity phosphatase Cdc25B; 3.1.3.48; CDC25HU2; MPIP2_MOUSE; Cdc25m2; MPIP2_RAT; cell division cycle 25B; CDC25 homolog B (S. pombe); M-phase inducer phosphatase 2

Rabbit

A synthesized peptide derived from human CDC25B: 175-250

IgG

Liquid

affinity purified by Protein A

Recombinant

9H7

65 kDa

55 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CDC25B

M-phase inducer phosphatase 2

Interacts with MAPK14 and 14-3-3 proteins.

Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.

Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.