ATF5 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,IP | Bioss

Rrmab?兔单抗
2026-03-02~2026-04-30,KXJ2603
ATF5 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,IP | Bioss
货号:bsm-61324R
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概述

产品编号
bsm-61324R
产品类型
重组兔单抗
英文名称
ATF5 Recombinant Rabbit mAb
中文名称
活化转录因子5重组兔单抗
英文别名
ATFX; HMFN0395; AFTA; Atf7; ODA-10; ATF5_HUMAN; ATF5; cAMP-dependent transcription factor ATF-5; Activating transcription factor 5; Transcription factor ATFx; ATF5_MOUSE; Activating transcription factor 5-alpha/beta; BZIP protein ATF7; NAP1; NRIF3-associated protein; Transcription factor-like protein ODA-10; ATF5_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ATF5: 200-282
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
10G1
理论分子量
31 kDa
检测分子量
31 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate.Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation.
活化转录因子5重组兔单抗-bsm-61324R活化转录因子5重组兔单抗-bsm-61324R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
Flow-CytHumanMouse, Rat1:50-100
IPHuman, Mouse, Rat1:20-50

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
ATF5
蛋白名
Cyclic AMP-dependent transcription factor ATF-5
亚基
Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.
亚细胞定位
Cytoplasmic and Nuclear
翻译后修饰
Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
相似性
Belongs to the bZIP family.
Contains 1 bZIP (basic-leucine zipper) domain.
功能
ATF5 or Activating transcription factor 5, binds to cAMP inducible promoters and is involved in gene transcription. This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF5 plays a role in inhibition of nerve growth factor induced neuronal outgrowth and regulation of neurogenesis.

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