Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate.Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
Flow-Cyt
Human
Mouse, Rat
1:50-100
IP
Human, Mouse, Rat
1:20-50
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
ATF5
蛋白名
Cyclic AMP-dependent transcription factor ATF-5
亚基
Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.
亚细胞定位
Cytoplasmic and Nuclear
翻译后修饰
Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
相似性
Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain.
功能
ATF5 or Activating transcription factor 5, binds to cAMP inducible promoters and is involved in gene transcription. This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF5 plays a role in inhibition of nerve growth factor induced neuronal outgrowth and regulation of neurogenesis.