钙/钙调素依赖蛋白激酶2α重组兔单抗
Rrmab®兔单抗
货号：bsm-61318R
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概述
产品编号
bsm-61318R
产品类型
重组兔单抗
英文名称
CaMK2 alpha Recombinant Rabbit mAb
中文名称
钙/钙调素依赖蛋白激酶2α重组兔单抗
英文别名
CAMKA; CaMKIINalpha; CaMKIIalpha; MRD53; MRT63; CAM2; CAMK2; CAMKB; CaMKIIbeta; MRD54; CAMKD; CAMK; CAMK-II; CAMKG; MRD59; 2810011D23Rik; 8030469K03Rik; CaMK II; [d]-CaMKII; CaMKII; mKIAA0968; Ck2b; CAMK1; Camki; RATCAMKI; PK2CDD; PKCCD; KCC2D_BOVIN; CAMK2D; CaM kinase II subunit delta; CaMK-II subunit delta; 2.7.11.17; KCC2B_BOVIN; CAMK2B; CaM kinase II subunit beta; CaMK-II subunit beta; KCC2B_HUMAN; KCC2G_HUMAN; CAMK2G; CaM kinase II subunit gamma; CaMK-II subunit gamma; KCC2D_HUMAN; KCC2A_HUMAN; CAMK2A; CaM kinase II subunit alpha; CaMK-II subunit alpha; KIAA0968; KCC2A_MOUSE; KCC2B_MOUSE; KCC2D_MOUSE; Kiaa4163; KCC2G_MOUSE; KCC2B_RAT; KCC2A_RAT; KCC2G_RAT; KCC2D_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human CaMKII alpha: 34-84
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5D17
理论分子量
54
检测分子量
54
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CaMK2b也是丝/苏氨基酸激酶的一种，同属于Ca++/钙调素依赖性蛋白质激酶家族成员。钙／钙调素依赖性蛋白激酶Ⅱb（CaMKⅡb）广泛分布于中枢神经系统内，参与调节神经递质的合成释放、信号转导和突触可塑性的形成以及磷酸化蛋白
背景资料
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation.Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CAMK2A
蛋白名
Calcium/calmodulin-dependent protein kinase type II subunit alpha
亚基
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.
亚细胞定位
Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts.
组织特异性
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
翻译后修饰
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
相似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
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