G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
OPRD1
蛋白名
delta-type opioid receptor
亚基
Interacts with GPRASP1.
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Abundant in lymphoid tissues.
翻译后修饰
Glycosylation is tissue specific. Sialylation of N-glycans at Asn-93 in brain and at Asn-42, Asn-93 and Asn-117 in thymus.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins.