Cortactin Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-61251R

重组兔单抗

Cortactin Recombinant Rabbit mAb

皮层肌动蛋白重组兔单抗

EMS1; SRC8_HUMAN; CTTN; Amplaxin; Oncogene EMS1; cortactin; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)

Rabbit

A synthesized peptide derived from human Src substrate cortactin: 30-84/550

IgG

Liquid

affinity purified by Protein A

Recombinant

7E5

62 kDa

75-80 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

皮层肌动蛋白（cortactin）是一种微丝肌动蛋白结合蛋白,其主要参与细胞骨架系统的调控,细胞外信号转导以及细胞黏附等过程,cortactin与肿瘤的侵袭和转移有关。

Cortactin a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches.

CTTN

Src substrate cortactin

Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts with DNM2 and FER. Binds to MYLK. A complex made of ABL1, CTTN and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement.

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle.

Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin. Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.

Contains 7 cortactin repeats.
Contains 1 SH3 domain.

Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.