Name: 磷脂酰乙醇胺结合蛋白1重组兔单抗（PEBP1 | PBP Recombinant Rabbit mAb）
Brand: 北京博奥森生物科技有限公司
SKU: bsm-61243R
Availability: InStock

概述

产品编号

bsm-61243R

产品类型

重组兔单抗

英文名称

PEBP1 | PBP Recombinant Rabbit mAb

中文名称

磷脂酰乙醇胺结合蛋白1重组兔单抗

英文别名

HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96; PBP; PEBP; PEBP-1; RKIP; Pbp1; Pbpr; PEBP1_HUMAN; PEBP1; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein (RKIP); PEBP1_MOUSE; PEBP1_RAT; 23 kDa morphine-binding protein; P23K; phosphatidylethanolamine binding protein 1; prostatic binding protein; Raf kinase inhibitory protein; hippocampal cholinergic neurostimulating peptide

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human PEBP1: 64-99

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

8B14

理论分子量

21 kDa

检测分子量

23 kDa

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

SWISS

P30086

Gene ID

5037

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 5037 Human

Entrez Gene : 23980 Mouse

Entrez Gene : 29542 Rat

Omim : 604591 Human

SwissProt : P30086 Human

SwissProt : P70296 Mouse

SwissProt : P31044 Rat

Unigene : 433863 Human

Unigene : 195898 Mouse

Unigene : 338476 Mouse

Unigene : 473809 Mouse

Unigene : 29745 Rat

产品介绍

信号传导（Signaling Intermediates）
Raf激酶抑制蛋白(PKIP)属于磷脂酰乙醇胺结合蛋白（phosphatidylethanolamine-binding protein, PEBP）家族,广泛存在于各种不同的生物中,PKIP还参与了对NF-kB信号通路和G蛋白偶联受体信号通路的调控,参与NF-κB信号通路的调控,参与了对细胞内多种信号转导通路的调节作用。RKIP在膜的生物合成、精子发生、神经发育和细胞凋亡等生理过程中发挥重要作用，并参与了老年痴呆症及糖尿病等的病理过程。有学者认为：RKIP有抑制肿瘤细胞转移的作用。

背景资料

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.

基因名

PEBP1

蛋白名

Phosphatidylethanolamine-binding protein 1

亚基

Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'.

亚细胞定位

Cytoplasm.

相似性

Belongs to the phosphatidylethanolamine-binding protein family.

功能

Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.