PBP Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,ICC/IF,IP | Bioss
Rrmab?兔单抗
货号：bsm-61243R
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概述
产品编号
bsm-61243R
产品类型
重组兔单抗
英文名称
PBP Recombinant Rabbit mAb
中文名称
磷脂酰乙醇胺结合蛋白1重组兔单抗
英文别名
HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96; PBP; PEBP; PEBP-1; RKIP; Pbp1; Pbpr; PEBP1_HUMAN; PEBP1; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein (RKIP); PEBP1_MOUSE; PEBP1_RAT; 23 kDa morphine-binding protein; P23K;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PEBP1: 64-99
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8B14
理论分子量
21 kDa
检测分子量
23 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Oncoproteins/suppressors > Tumor suppressors
Cell Biology > Cell Cycle > Cell Division > Spindle
Cell Biology > Cell Cycle > Kinases/Phosphatases
Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases
Neuroscience > Neurotransmitter > Acetylcholine
Neuroscience > Neurotransmitter > Neuropeptides > More Neuropeptides
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
信号传导（Signaling Intermediates）
Raf激酶抑制蛋白(PKIP)属于磷脂酰乙醇胺结合蛋白 （phosphatidylethanolamine-binding protein, PEBP）家族,广泛存在于各种不同的生物中,PKIP还参与了对NF-kB信号通路和G蛋白偶联受体信号通路的调控,参与NF-κB信号通路的调控,参与了对细胞内多种信号转导通路的调节作用。RKIP在膜的生物合成、精子发生、神经发育和细胞凋亡等生理过程中发挥重要作用，并参与了老年痴呆症及糖尿病等的病理过程。有学者认为：RKIP有抑制肿瘤细胞转移的作用。
Raf激酶抑制蛋白(PKIP)属于磷脂酰乙醇胺结合蛋白 （phosphatidylethanolamine-binding protein, PEBP）家族,广泛存在于各种不同的生物中,PKIP还参与了对NF-kB信号通路和G蛋白偶联受体信号通路的调控,参与NF-κB信号通路的调控,参与了对细胞内多种信号转导通路的调节作用。RKIP在膜的生物合成、精子发生、神经发育和细胞凋亡等生理过程中发挥重要作用，并参与了老年痴呆症及糖尿病等的病理过程。有学者认为：RKIP有抑制肿瘤细胞转移的作用。
背景资料
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PEBP1
蛋白名
Phosphatidylethanolamine-binding protein 1
亚基
Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'.
亚细胞定位
Cytoplasm.
相似性
Belongs to the phosphatidylethanolamine-binding protein family.
功能
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
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