乙酰辅酶A羧化酶重组兔单抗
Rrmab®兔单抗
货号：bsm-61228R
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概述
产品编号
bsm-61228R
产品类型
重组兔单抗
英文名称
ACACA Recombinant Rabbit mAb
中文名称
乙酰辅酶A羧化酶重组兔单抗
英文别名
ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta; HACC275; A530025K05Rik; Acac; Acc1; Gm738; ACACA_HUMAN; ACACA; Acetyl-Coenzyme A carboxylase alpha (ACC-alpha); 6.4.1.2; ACCA; ACACA_MOUSE; ACC-alpha; Acetyl-CoA carboxylase 265; ACACA_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ACACA: 370-430/2346
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
17C5
理论分子量
266,277
检测分子量
265
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Synthesis
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:200-800 | |
| IHC-F | Human, Mouse, Rat | 1:200-800 | |
| IF | Human, Mouse, Rat | 1:200-800 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ACACA
蛋白名
Acetyl-CoA carboxylase 1
亚基
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
亚细胞定位
Cytoplasm.
组织特异性
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
翻译后修饰
Phosphorylation on Ser-1263 is required for interaction with BRCA1.
疾病
Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.
相似性
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
功能
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
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