促代谢型谷氨酸受体5重组兔单抗
Rrmab®兔单抗
货号：bsm-61218R
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概述
产品编号
bsm-61218R
产品类型
重组兔单抗
英文名称
mGluR5 Recombinant Rabbit mAb
中文名称
促代谢型谷氨酸受体5重组兔单抗
英文别名
GPRC1E; MGLUR5; PPP1R86; mGlu5; 6430542K11Rik; Glu5R; mGluR5b; GRM5_HUMAN; GRM5; GRM5_MOUSE; GRM5_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human mGluR5: 1180-1212
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
理论分子量
132
检测分子量
132
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
GRM5
蛋白名
Metabotropic glutamate receptor 5
亚基
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity).
亚细胞定位
Cell Membrane
相似性
Belongs to the G-protein coupled receptor 3 family.
功能
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates
a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
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