溶酶体相关膜蛋白2（CD107B）重组兔单抗
Rrmab®兔单抗
货号：bsm-61207R
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概述
产品编号
bsm-61207R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
LAMP2 Recombinant Rabbit mAb
中文名称
溶酶体相关膜蛋白2（CD107B）重组兔单抗
英文别名
CD107b; DND; LAMP-2; LAMPB; LGP-96; LGP110; LGP-B; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c; Mac3; LAMP2_HUMAN; LAMP2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; LAMP2_MOUSE; Lysosomal membrane glycoprotein type B (LGP-B);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human LAMP2: 370-410
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9C18
理论分子量
45
检测分子量
120
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Autophagy > Autophagosome
Cardiovascular > Heart > Autophagy > Autophagosome
Immunology > Secreted Molecules > Other secreted molecules
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > Autophagosome
Signal Transduction > Metabolism > Energy Metabolism
Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Myeloid Progenitor
Tags & Cell Markers > Subcellular Markers > Organelles > Lysosome
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
LAMP2
蛋白名
Lysosome-associated membrane glycoprotein 2
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
翻译后修饰
O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans.
相似性
Belongs to the LAMP family.
功能
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
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