HSPA8 | HSC70 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,ICC/IF,IF,IP | Bioss

bsm-61188R

重组兔单抗

HSPA8 | HSC70 Recombinant Rabbit mAb

热休克蛋白71重组兔单抗

HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71; 2410008N15Rik; Hsc73; HSP7C_HUMAN; HSPA8; Heat shock 70 kDa protein 8; Heat shock protein family A member 8; Lipopolysaccharide-associated protein 1 (LAP-1 | LPS-associated protein 1); 3.6.4.10; HSP7C_MOUSE; HSP7C_RAT; heat shock protein family A (Hsp70) member 8; heat shock 70kD protein 8; heat shock 70kDa protein 8

Rabbit

A synthesized peptide derived from human Hsc70: 600-646/646

IgG

Liquid

affinity purified by Protein A

Recombinant

11D8

71 kDa

70 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.

HSPA8

Heat shock cognate 71 kDa protein

Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.

Cytoplasm. Melanosome.

Ubiquitous.

Phosphorylated upon DNA damage, probably by ATM or ATR. ISGylated.

Belongs to the heat shock protein 70 family.

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.