TSPO Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss
Rrmab?兔单抗
货号：bsm-61187R
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概述
产品编号
bsm-61187R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
TSPO Recombinant Rabbit mAb
中文名称
TSPO蛋白重组兔单抗
英文别名
BPBS; BZRP; DBI; IBP; MBR; PBR; PBS; PKBS; PTBR; TSPO1; mDRC; pk18; TSPOB_HUMAN; TSPO; PBRS; TSPO_HUMAN; Mitochondrial benzodiazepine receptor; Peripheral-type benzodiazepine receptor (PBR); TSPO_MOUSE; translocator protein; benzodiazapine receptor (peripheral); translocator protein (18kDa); peripheral-type benzodiazepine receptor/recognition site
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human TSPO: 100-169
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12B8
理论分子量
19 kDa
检测分子量
15 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Cell Death > Apoptosis > Mitochondrial
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism
Cell Biology > Apoptosis > Mitochondrial
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
Metabolism > Types of disease > Cancer
Signal Transduction > Metabolism > Lipid metabolism
Signal Transduction > Metabolism > Mitochondrial
Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
地西泮结合抑制因子；
DBI能拮抗安定物质：diazepam与脑突触膜相结合 ,故称之为安定结合抑制蛋白(DBI)，地西泮结合抑制因子(diazepam binding inhibitor,DBI)具有抑制由葡萄糖诱导的胰岛素分泌、促进胆固醇跨线粒体膜转运和调节脂肪酸合成与代谢等多种生理功能。
背景资料
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme.Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.
基因名
TSPO
蛋白名
Putative peripheral benzodiazepine receptor-related protein
亚基
Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.
亚细胞定位
Mitochondrion membrane.
组织特异性
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.
相似性
Belongs to the TspO/BZRP family.
功能
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| IHC-P | Human, Mouse | 1:100-500 | |
| IHC-F | Human, Mouse | 1:100-500 | |
| IF | Human, Mouse | 1:100-500 | |
| Flow-Cyt | Human | Mouse | 1:50-100 |
| ICC/IF | Human | Mouse | 1:50-200 |
| IP | Human, Mouse | 1:20-50 |
交叉反应
交叉反应: Human, Mouse
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