微管蛋白γ重组兔单抗
Rrmab®兔单抗
货号：bsm-61186R
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概述
产品编号
bsm-61186R
产品类型
重组兔单抗、宠物抗体、模式动物抗体、农牧业/家禽抗体、水生生物抗体
英文名称
Gamma Tubulin Recombinant Rabbit mAb
中文名称
微管蛋白γ重组兔单抗
英文别名
CDCBM4; GCP-1; TUBG; TUBGCP1; 1500010O08Rik; Tubgl; TBG1_HUMAN; TUBG1; Gamma-1-tubulin; Gamma-tubulin complex component 1 (GCP-1); TBG2_HUMAN; TUBG2; Gamma-2-tubulin; TBG1_MOUSE; TBG2_MOUSE; TBG1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human gamma 1 Tubulin: 200-451/451
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2B11
理论分子量
51
检测分子量
48
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
结构蛋白（Structural Proteins）
gamma tubulin 微管蛋白是存于中心体的另一种微管蛋白, gamma微管蛋白对微管的形成具有重要作用。gamma微管蛋白通过与β-微管蛋白的相互作用帮助微管的成核反应(nucleation)。即在微管的组装中gamma微管蛋白先形成一个圆或形成钩环结构, γ微管蛋白的这种结构可指导微管蛋白二聚体结合上去并进行微管的组装。gamma微管蛋白在微管的组装中起关键作用。
gamma tubulin 微管蛋白是存于中心体的另一种微管蛋白, gamma微管蛋白对微管的形成具有重要作用。gamma微管蛋白通过与β-微管蛋白的相互作用帮助微管的成核反应(nucleation)。即在微管的组装中gamma微管蛋白先形成一个圆或形成钩环结构, γ微管蛋白的这种结构可指导微管蛋白二聚体结合上去并进行微管的组装。gamma微管蛋白在微管的组装中起关键作用。
背景资料
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:50-200 |
| IHC-F | Human, Mouse, Rat | Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:50-200 |
| IF | Human, Mouse, Rat | Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:50-200 |
| Flow-Cyt | Human, Mouse, Rat, Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat, Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:50-200 | |
| IP | Human, Mouse, Rat, Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Cow, Zebrafish, Chicken, Dog, Hamster, Monkey, Xenopus)
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靶标
基因名
TUBG1
蛋白名
Tubulin gamma-1 chain
亚基
Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO.
亚细胞定位
Cytoplasm, cytoskeleton, centrosome.
组织特异性
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
翻译后修饰
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
相似性
Belongs to the tubulin family.
功能
Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation.
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