Bak Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF,IP | Bioss

bsm-61174R

重组兔单抗、mIHC精品抗体

Bak Recombinant Rabbit mAb

Bcl-2同源拮抗剂重组兔单抗

BAK; BAK-LIKE; BCL2L7; CDN1; N-BAK1; N-Bak; BAK_HUMAN; BAK1; Apoptosis regulator BAK; Bcl-2-like protein 7 (Bcl2-L-7); BAK_MOUSE; BCL2 antagonist/killer 1; BCL2-antagonist/killer 1

Rabbit

A synthesized peptide derived from human BAK1: 1-48

IgG

Liquid

affinity purified by Protein A

Recombinant

5C2

23 kDa

25 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Bak属于bcl-2基因家族中的成员，具有抑制凋亡的作用。BAK基因是新发现的细胞凋亡促进因子，BAK含BH1和BH2结构域，其功能类似于BAX；拮抗BCL2、BCL-XL的抗凋亡效应。

Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.

BAK1

Bcl-2 homologous antagonist/killer

Belongs to the Bcl-2 family.

Mitochondrion membrane.

Expressed in a wide variety of tissues.

Belongs to the Bcl-2 family.

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.