PTPN6 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
Rrmab?兔单抗
货号：bsm-61171R
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概述
产品编号
bsm-61171R
产品类型
重组兔单抗
英文名称
PTPN6 Recombinant Rabbit mAb
中文名称
蛋白酪氨酸磷酸酶1C重组兔单抗
英文别名
HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; 70Z-SHP; PTPTY-42; Ptp1C; me; Ptph6; PTN6_HUMAN; PTPN6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C (PTP-1C); Protein-tyrosine phosphatase SHP-1; 3.1.3.48; PTN6_MOUSE; SH-PTP1 (SHP-1); PTN6_RAT; protein tyrosine phosphatase non-receptor type 6
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SHP1: 520-595
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
7F10
理论分子量
68 kDa
检测分子量
65 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell cycle > Kinases/phosphatases > Phosphatases
Cancer > Signal transduction > G protein signaling > GPCR
Cell Biology > Cell Cycle > Kinases/Phosphatases > Phosphatases
Developmental Biology > Organogenesis > Hematopoietic system development
Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
蛋白酪氨酸磷酸酶1(SHP-1)能是一个潜在的抑癌基因，它负性调节c-kit基因而抑制肿瘤的发生;
SHP-1为含SH2域(src homology-2 domain)的酪氨酸磷酸酶-1，主要表达于造血细胞，因此又称为造血细胞磷酸酶（hematopoietic cell phosphatase，HCP，也称为SHP-1或SHPTP1）。
SHP-1为含SH2域(src homology-2 domain)的酪氨酸磷酸酶-1，主要表达于造血细胞，因此又称为造血细胞磷酸酶（hematopoietic cell phosphatase，HCP，也称为SHP-1或SHPTP1）。
背景资料
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PTPN6
蛋白名
Tyrosine-protein phosphatase non-receptor type 6
亚基
Monomer. Interacts with MTUS1. Interacts with MILR1 (tyrosine-phosphorylated). Interacts with KIT. Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF, CDK2 and CD84. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation. Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with LYN. Interacts with the tyrosine phosphorylated form of PDPK1.
亚细胞定位
Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK1.
组织特异性
Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
翻译后修饰
Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 enhances phosphatase activity.
相似性
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
功能
Modulates signaling by tyrosine phosphorylated cellcsurface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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