细胞粘合素(固生蛋白)重组兔单抗
Rrmab®兔单抗
货号：bsm-61165R
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概述
产品编号
bsm-61165R
产品类型
重组兔单抗
英文名称
Tenascin Recombinant Rabbit mAb
中文名称
细胞粘合素(固生蛋白)重组兔单抗
英文别名
150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C; C130033P17Rik; Ten; cytotactin; tenascin-C; TENA_HUMAN; TNC; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; Myotendinous antigen; Neuronectin; Tenascin-C (TN-C); TENA_MOUSE; B2LYI9_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Tenascin: 2188-2201/2201
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
13B19
理论分子量
241
检测分子量
241
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
Tenascin-C(TN-C)是重要的细胞外基质(ECM)成分之一,在组织器官的发生发育中发挥着极其重要的作用;其表达具有复杂的时空分布,并受多种因素(细胞因子、激素等)调节.目前主要用于消化系统肿瘤方面的研究。
背景资料
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
TNC
蛋白名
Tenascin
亚基
Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
亚细胞定位
Secreted, extracellular space, extracellular matrix.
组织特异性
Brain specific.
翻译后修饰
Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.
相似性
Belongs to the tenascin family.
Contains 15 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 15 fibronectin type-III domains.
Contains 15 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 15 fibronectin type-III domains.
功能
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
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