组织蛋白酶D重组兔单抗
Rrmab®兔单抗
货号：bsm-61164R
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概述
产品编号
bsm-61164R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Cathepsin D Recombinant Rabbit mAb
中文名称
组织蛋白酶D重组兔单抗
英文别名
CLN10; CPSD; HEL-S-130P; CD; CatD; CATD_HUMAN; CTSD; 3.4.23.5; CATD_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Cathepsin D: 360-412/412
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6D8
理论分子量
45
检测分子量
46,28
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Invasion/microenvironment > ECM > Extracellular matrix
Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Cysteine protease > Cathepsins
Neuroscience > Cell Adhesion Proteins > Membrane Proteins
Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 | |
| IHC-P | Human, Mouse | 1:100-500 | |
| IHC-F | Human, Mouse | 1:100-500 | |
| IF | Human, Mouse | 1:100-500 | |
| Flow-Cyt | Human, Mouse | 1:50-100 | |
| ICC/IF | Human, Mouse | 1:50-200 | |
| IP | Human, Mouse | 1:20-50 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
CTSD
蛋白名
Cathepsin D
亚细胞定位
Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
组织特异性
Expressed in the aorta extrcellular space (at protein level).
翻译后修饰
N- and O-glycosylated.
疾病
Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10); also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
相似性
Belongs to the peptidase A1 family.
功能
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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