Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse, Rat
Human
1:500-2000
IHC-P
Human, Mouse, Rat
1:50-200
IHC-F
Human, Mouse, Rat
1:50-200
IF
Human, Mouse, Rat
1:50-200
Flow-Cyt
Human, Mouse, Rat
1:50-100
IP
Human, Mouse, Rat
1:20-50
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
GLUL
蛋白名
Glutamine synthetase
亚细胞定位
Cytoplasm. Mitochondrion.
疾病
Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
相似性
Belongs to the glutamine synthetase family.
功能
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.