DAPK1 Recombinant Rabbit mAb (一抗) - IHC-P,IHC-F,IF | Bioss

bsm-61153R

重组兔单抗

DAPK1 Recombinant Rabbit mAb

死亡相关蛋白激酶1重组兔单抗

DAPK; ROCO3; D13Ucla1; DAP-Kinase; DAPK1_HUMAN; DAPK1; DAP kinase 1; 2.7.11.1; DAPK1_MOUSE; death associated protein kinase 1; death-associated protein kinase 1

Rabbit

A synthesized peptide derived from human DAP kinase 1: 300-350/1430

IgG

Liquid

affinity purified by Protein A

Recombinant

6C11

160 kDa

160 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

凋亡相关蛋白激酶1(DAPK1)又称：一般性白血病的基因，也是一种肿瘤抑制基因，广泛存在于各种细胞的凋亡系统中，该基因正常情况下有助于触发细胞在发生癌变前就死亡。但异常的DNA甲基化作用会关闭控制细胞生长的DAPK1基因，从而造成肿瘤生长。

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1.

DAPK1

Death-associated protein kinase 1

Interacts with KLHL20. Interacts (via death domain) with MAPK1 and MAPK3. Interacts with MAP1B (via N-terminus). Interacts (via death domain) with UNC5B (via death domain). Interacts with PRKD1 in an oxidative stress-regulated manner. Interacts with PIN1, PDCD6, BECN1, GRINB, TSC2 and STX1A. Interacts (via kinase domain) with DAPK3 (via kinase domain).

Cytoplasm. Colocalizes with the actin filament system.

Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.

Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.

Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
DAP kinase subfamily.

Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.