凋亡蛋白活性因子-1重组兔单抗
Rrmab®兔单抗
货号：bsm-61152R
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概述
产品编号
bsm-61152R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
APAF1 Recombinant Rabbit mAb
中文名称
凋亡蛋白活性因子-1重组兔单抗
英文别名
APAF-1; CED4; 6230400I06Rik; Apaf1l; fog; mKIAA0413; APAF_HUMAN; APAF1; KIAA0413; APAF_MOUSE; APAF_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human APAF 1: 1-35
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1D10
理论分子量
142
检测分子量
135
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell Death > Apoptosis > Apoptosis Markers > Cytochrome C
Cancer > Cell Death > Apoptosis > Metabolism
Cancer > Cell Death > Apoptosis > Mitochondrial
Cancer > Invasion/microenvironment > Apoptosis > Cytochrome C
Cell Biology > Apoptosis > Mitochondrial
Metabolism > Pathways and Processes > Metabolism processes > Apoptosis
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
Apaf-1 （Apoptosis protease activating factor-1）调节细胞色素C依赖的Caspase-9原的自动催化活性，导致Caspase-3 的激活和引起凋亡。
Apaf-1在成年人的脾脏、外周血白细胞、肾脏、肺和胎儿脑、肾、肺中高水平表达。
Apaf-1在成年人的脾脏、外周血白细胞、肾脏、肺和胎儿脑、肾、肺中高水平表达。
背景资料
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse | 1:500-2000 |
| IHC-P | Human, Mouse | 1:100-500 | |
| IHC-F | Human, Mouse | 1:100-500 | |
| IF | Human, Mouse | 1:100-500 | |
| ICC/IF | Human | Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
APAF1
蛋白名
Apoptotic protease-activating factor 1
亚基
Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain).
亚细胞定位
Cytoplasm.
组织特异性
Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
相似性
Contains 1 CARD domain.
Contains 1 NB-ARC domain.
Contains 13 WD repeats.
Contains 1 NB-ARC domain.
Contains 13 WD repeats.
功能
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
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