钙调节素重组兔单抗
Rrmab®兔单抗
货号：bsm-61141R
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概述
产品编号
bsm-61141R
产品类型
重组兔单抗
英文名称
Calmodulin 1 Recombinant Rabbit mAb
中文名称
钙调节素重组兔单抗
英文别名
CALML2; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; CPVT4; DD132; LQT14; PHKD; PHKD1; caM; Calm; Cam1; CALM1_HUMAN; CALM1; CALM1_MOUSE; CALM1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Calmodulin 1: 100-149
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
8D11
理论分子量
17
检测分子量
17
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates
Cardiovascular > Atherosclerosis > Apoptosis
Cardiovascular > Heart > Cardiac metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism
Metabolism > Types of disease > Cancer
Metabolism > Types of disease > Heart disease
Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins
Signal Transduction > Signaling Pathway > Calcium Signaling > Calmodulin Pathway
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
钙离子调节素（calmodulin,CaM）: 钙调蛋白（CaM），是由一条多肽链组成的单体蛋白。可结合4个Ca2+，胞浆Ca2+浓度≥10-2mmol/L时，Ca2+与CaM结合，构象改变而激活Ca2+ -CaM激酶。
背景资料
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| Flow-Cyt | Human, Mouse, Rat | 1:50-100 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CALM1
蛋白名
Calmodulin-1
亚基
Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2.
亚细胞定位
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
翻译后修饰
Ubiquitination results in a strongly decreased activity.
Phosphorylation results in a decreased activity.
Phosphorylation results in a decreased activity.
相似性
Belongs to the calmodulin family. Contains 4 EF-hand domains.
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