热休克蛋白90β/HSP90 β 重组兔单抗
Rrmab®兔单抗
货号：bsm-61128R
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概述
产品编号
bsm-61128R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
HSP90 beta Recombinant Rabbit mAb
中文名称
热休克蛋白90β/HSP90 β 重组兔单抗
英文别名
D6S182; HSP84; HSP90B; HSPC2; HSPCB; 90kDa; Hsp84-1; Hsp90; HSP90-BETA; HS90B_HUMAN; HSP90AB1; HSP 90; Heat shock 84 kDa (HSP 84 | HSP84); Heat shock protein family C member 3; HSPC3; HS90B_MOUSE; Tumor-specific transplantation 84 kDa antigen (TSTA); HS90B_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Hsp90 beta: 500-724
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
13E19
理论分子量
83
检测分子量
85
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
HSP是细胞受应激原刺激后诱导产生的一组应激蛋白，与肿瘤发生、增殖及分化有关，HSP90β能够抑制细胞凋亡与分化。
背景资料
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:1000-5000 | |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human | Mouse, Rat | 1ug/Test |
| ICC/IF | Human | Mouse, Rat | 1:100-500 |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
HSP90AB1
蛋白名
Heat shock protein HSP 90-beta
亚基
Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4.
亚细胞定位
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
翻译后修饰
Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity (Probable).
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity (Probable).
相似性
Belongs to the heat shock protein 90 family.
功能
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
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