凋亡抑制因子2重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
凋亡抑制因子2重组兔单抗
货号:bsm-61124R
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概述

产品编号
bsm-61124R
产品类型
重组兔单抗
英文名称
API2/BIRC3 Recombinant Rabbit mAb
中文名称
凋亡抑制因子2重组兔单抗
英文别名
AIP1; API2; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; MIHC; RNF49; c-IAP2; Api1; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; cIAP-1; cIAP-2; cIAP1; Birc2; BIRC3_HUMAN; BIRC3; Apoptosis inhibitor 2 (API2); Cellular inhibitor of apoptosis 2 (C-IAP2); IAP homolog C; Inhibitor of apoptosis protein 1 (hIAP-1 | hIAP1); RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1; 2.3.2.27; BIRC3_MOUSE; Inhibitor of apoptosis protein 1 (mIAP1);
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human BIRC3: 400-450/604
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
6C19
理论分子量
68
检测分子量
72
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.
凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗凋亡抑制因子2重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000
IHC-PHuman1:50-200
IHC-FHuman1:50-200
IFHuman1:50-200
ICC/IFHuman1:50-100
IPHuman1:20-50

交叉反应

交叉反应: Human

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靶标

基因名
BIRC3
蛋白名
Baculoviral IAP repeat-containing protein 3
亚基
Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
亚细胞定位
Cytoplasm. Nucleus.
组织特异性
Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
疾病
Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
相似性
Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 CARD domain.
Contains 1 RING-type zinc finger.
功能
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).

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