少突胶质细胞转录因子2重组兔单抗
Rrmab®兔单抗
货号：bsm-61115R
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概述
产品编号
bsm-61115R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
OLIG2 Recombinant Rabbit mAb
中文名称
少突胶质细胞转录因子2重组兔单抗
英文别名
BHLHB1; OLIGO2; PRKCBP2; RACK17; bHLHe19; Olg-2; RK17; wu:fc64g09; OLIG2_HUMAN; OLIG2; Class B basic helix-loop-helix protein 1 (bHLHb1); Class E basic helix-loop-helix protein 19 (bHLHe19); Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17; OLIG2_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Oligo2: 240-323/323
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5A15
理论分子量
32
检测分子量
32
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:50-200 | |
| IHC-F | Human, Mouse, Rat | 1:50-200 | |
| IF | Human, Mouse, Rat | 1:50-200 | |
| ICC/IF | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
OLIG2
蛋白名
Oligodendrocyte transcription factor 2
亚基
Contains 1 basic helix-loop-helix (bHLH) domain.
亚细胞定位
Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
组织特异性
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
疾病
Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
相似性
Contains 1 basic helix-loop-helix (bHLH) domain.
功能
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
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