半乳糖凝集素3重组兔单抗

Rrmab^®兔单抗

2026-01-04~2026-02-28，RR26012026-01-04~2026-02-28，TR

一键复制说明书

货号：bsm-61087R

产品详情

概述

产品编号

bsm-61087R

产品类型

重组兔单抗、mIHC精品抗体

英文名称

Galectin 3 Recombinant Rabbit mAb

中文名称

半乳糖凝集素3重组兔单抗

英文别名

CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; GBP; L-34; Mac-2; AGE-R3; CBP30; gal-3; LEG3_HUMAN; LGALS3; 35 kDa lectin; Carbohydrate-binding protein 35 (CBP 35); Galactose-specific lectin 3; Galactoside-binding protein (GALBP); IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LEG3_MOUSE; L-34 galactoside-binding lectin; LEG3_RAT;

抗体来源

Rabbit

免疫原

A synthesized peptide derived from human Galectin 3: 160-190

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Recombinant

克隆号

5C5

理论分子量

29 kDa

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Cell Biology > Cell Cycle > Cell differentiation

Neuroscience > Cell Adhesion Proteins > Nuclear Proteins

SWISS

P17931

Gene ID

3958

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 3958 Human

Entrez Gene : 16854 Mouse

Entrez Gene : 83781 Rat

Omim : 153619 Human

SwissProt : P17931 Human

SwissProt : P16110 Mouse

SwissProt : P08699 Rat

Unigene : 531081 Human

Unigene : 248615 Mouse

Unigene : 764 Rat

产品介绍

Galectin-3是Galectin（半乳凝素）家族的一员，能识别糖蛋白和糖脂的特异性低聚糖结构，参与多种生理和病理过程，包括细胞生长和凋亡、细胞黏附、新生血管形成和肿瘤浸润与转移等。Galectin-3在肿瘤的发生、发展及转移中起重要作用。 Galectin-3在某些肿瘤组织中高表达，其在不同类型肿瘤，如结直肠癌、胃癌、胰腺癌、甲状腺癌及肺癌等患者中的高表达水平，与低生存、肿瘤复发、预后差及对化疗药物敏感性降低相关对于某些肿瘤，Galectin-3有可能成为一个有价值的诊断标志和治疗靶点。

背景资料

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

产品应用

应用	已检合格种属	推荐稀释比例
WB	Human	1:1000-5000
IHC-P	Human	1:200-800
IHC-F	Human	1:200-800
IF	Human	1:200-800

交叉反应

交叉反应: Human

靶标

基因名

LGALS3

蛋白名

Galectin-3

亚基

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

亚细胞定位

Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

组织特异性

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.

相似性

Contains 1 galectin domain.

功能

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

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半乳糖凝集素3重组兔单抗

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交叉反应

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