核因子2相关因子2重组兔单抗
Rrmab®兔单抗
货号：bsm-61093R
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概述
产品编号
bsm-61093R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Nrf2 Recombinant Rabbit mAb
中文名称
核因子2相关因子2重组兔单抗
英文别名
HEBP1; IMDDHH; NRF2; Nrf-2; NF2L2_HUMAN; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Nrf2: 550-605/605
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
20H5
理论分子量
68 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Heart > Cardiac metabolism
Cell Biology > Other Antibodies > Oxidative Stress
Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies
Epigenetics and Nuclear Signaling > Transcription > Other factors
Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Molecular processes > Mitochondrial transcription
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial Biogenesis
Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
转录调节因子（Transcriptin Regulators）
核细胞系因子2相关因子Nrf2，是一种对氧化还原反应敏感的转录因子，可以通过正向促进基因的表达，来转录翻译产生一些抗氧化物，行使着异化解毒的酶类和药物的高效外排泵作用。
有学者认为：核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用，它指导某些基因促进细胞的防御工事，同时也刺激某些重要解毒酶对毒性物质，如黄曲霉素的解毒和排毒作用。
有学者认为：核因子2相关因子2蛋白在保护细胞免受环境毒性物质影响方面发挥着极其重要的作用，它指导某些基因促进细胞的防御工事，同时也刺激某些重要解毒酶对毒性物质，如黄曲霉素的解毒和排毒作用。
背景资料
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription
factor which regulates the expression of many detoxification and
antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar (CNC-bZIP) subfamily of basic /leucine zipper (bZIP) transcription factors.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:1000-5000 | |
| IHC-P | Human, Mouse, Rat | 1:200-1000 | |
| IHC-F | Human, Mouse, Rat | 1:200-1000 | |
| IF | Human, Mouse, Rat | 1:200-1000 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| ICC/IF | Human | Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
NFE2L2
蛋白名
Nuclear factor erythroid 2-related factor 2
亚基
Heterodimer. Forms a ternary complex with PGAM5 and KEAP1. May bind DNA with an unknown protein. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
亚细胞定位
Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
组织特异性
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
翻译后修饰
Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
相似性
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
Contains 1 bZIP domain.
功能
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
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