自噬效应蛋白Beclin 1重组兔单抗

bsm-61085R

重组兔单抗

Beclin 1 Recombinant Rabbit mAb

自噬效应蛋白Beclin 1重组兔单抗

ATG6; VPS30; beclin1; BECN1_HUMAN; BECN1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197; GT197; BECN1_MOUSE; BECN1_RAT;

Rabbit

A synthesized peptide derived from human Beclin 1: 400-450

IgG

Liquid

affinity purified by Protein A

Recombinant

6A20

50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BECN1是一种分子质量为60KDa的蛋白质, 它能与细胞凋亡抑制剂Bcl-2相互作用, 减少中枢神经系统的凋亡，参与PI3K复合物的组成和自噬体的形成。主要表达在胞质。抑癌基因beclin 1通过自噬作用来调节细胞生长。

Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.