平滑肌肌球蛋白重链抗体

bsm-54033R

重组兔单抗、mIHC精品抗体

smooth muscle Myosin heavy chain 11 Recombinant Rabbit mAb

平滑肌肌球蛋白重链抗体

AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2; SM1; SM2; MYH11_HUMAN; MYH11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; KIAA0866; MYH11_MOUSE; MYH11_RABIT; MYH11_RAT;

Rabbit

A synthesized peptide derived from human Myosin heavy chain 11: 2-34

IgG

Liquid

affinity purified by Protein A

Recombinant

1F11

227 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

平滑肌肌球蛋白重链是分子量为200kDa的多肽，是六聚肌球蛋白的结构成分。主要用于标记血管和内脏平滑肌细胞以及肌上皮细胞，被认为是平滑肌较为特异和可靠的标志，有助于间叶肿瘤的诊断和分类，也可用于乳腺肌上皮细胞的检测，有助于原位癌和浸润癌的区别鉴定。

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.
MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.