多药耐药相关蛋白2重组兔单抗

bsm-61068R

重组兔单抗

MRP2 Recombinant Rabbit mAb

多药耐药相关蛋白2重组兔单抗

ABC30; CMOAT; DJS; MRP2; cMRP; mrp; MRP2_HUMAN; ABCC2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; 7.6.2.-; 7.6.2.2; 7.6.2.3; CMOAT1; MRP2_MOUSE; MRP2_RAT;

Rabbit

A synthesized peptide derived from human ABCC2: 1500-1545

IgG

Liquid

affinity purified by Protein A

Recombinant

14F18

174 kDa

1mg/ml

0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MRP-2作为一种结合输出泵，转运许多不同的药物结合物的蛋白。
MRP2蛋白的染色阳性产物分布于细胞浆/膜中。

multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family.