RORC Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss
货号：bs-6217R
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概述
产品编号
bs-6217R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
RORC Rabbit pAb
中文名称
维甲酸相关孤儿受体γ抗体
英文别名
IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR; RORgamma; Thor; RORG_HUMAN; RORC; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; RORG_MOUSE; Thymus orphan receptor (TOR); RAR related orphan receptor C; Nuclear receptor ROR-gamma
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human RORC: 415-518/518
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
57 kDa
检测分子量
55 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Rat | Human, Mouse, Pig, Cow, Dog, Horse | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Pig, Cow, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Pig, Cow, Dog, Horse | 1ug/test |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Pig, Cow, Dog, Horse)
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靶标
基因名
RORC
蛋白名
Nuclear receptor ROR-gamma
亚细胞定位
Nucleus (Probable).
组织特异性
Isoform 1: widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2: Primarily expressed in immature thymocytes.
相似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Contains 1 nuclear receptor DNA-binding domain.
功能
Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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