phospho-Vimentin (Ser56) Rabbit pAb (一抗) | Bioss
货号：bs-3471R
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常见问题
概述
产品编号
bs-3471R
产品类型
磷酸化抗体
英文名称
phospho-Vimentin (Ser56) Rabbit pAb
中文名称
磷酸化波形蛋白抗体
英文别名
VIM | Vimentin (phospho-S56); p-Vimentin; phospho-Vimentin; p-VIM; VIM | Vimentin (phospho-Ser56); VIME_HUMAN; VIM; VIME_MOUSE; VIME_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human Vimentin around the phosphorylation site of Ser56: S(p-S)PG
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
51 kDa
检测分子量
55 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Developmental Biology > Lineage specification > Ectoderm
Neuroscience > Cell Type Marker > Neural Stem Cell marker
Neuroscience > Neurology process > Neurogenesis
Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration
Signal Transduction > Antibodies > vimentin
Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class III > Vimentin
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
背景资料
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| Flow-Cyt | Human | Mouse, Rat | 0.2μg /Test |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
VIM
蛋白名
Vimentin
亚基
Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity).
亚细胞定位
Cytoplasm.
组织特异性
Highly expressed in fibroblasts, somev expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
翻译后修饰
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
疾病
Cataract 30 (CTRCT30)
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
The disease is caused by mutations affecting the gene represented in this entry.
Disease description:An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
相似性
Belongs to the intermediate filament family.
功能
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
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